Randomized Double-Blind Phase III Trial of Vitamin D3 Supplementation in Patients With Previously Untreated Metastatic Colorectal Cancer (SOLARIS)

This phase III trial studies how well vitamin D3 given with standard chemotherapy and
bevacizumab works in treating patients with colorectal cancer that has spread to other
parts of the body. Vitamin D3 helps the body use calcium and phosphorus to make strong
bones and teeth. Drugs used in chemotherapy, such as leucovorin calcium, fluorouracil,
oxaliplatin, and irinotecan hydrochloride, work in different ways to stop the growth of
tumor cells by killing the cells, by stopping them from dividing, or by stopping them
from spreading. Immunotherapy with monoclonal antibodies, such as bevacizumab, may help
the body's immune system attack the cancer, and may interfere with the ability of tumor
cells to grow and spread. Giving vitamin D3 with chemotherapy and bevacizumab may work
better in shrinking or stabilizing colorectal cancer. It is not yet known whether giving
high-dose vitamin D3 in addition to chemotherapy and bevacizumab would extend patients'
time without disease compared to the usual approach (chemotherapy and bevacizumab).

Inclusion Criteria:

- Histologically confirmed advanced/metastatic colorectal adenocarcinoma for which
metastasectomy is not planned.

- No known mismatch repair deficiency (dMMR) or high-frequency microsatellite
instability (MSI-H) disease.

- Measurable disease per Response Evaluation Criteria in Solid Tumors (RECIST) version
(v) 1.1.

- No prior systemic treatment for metastatic disease.

- Patients may have received prior neoadjuvant or adjuvant chemotherapy and/or
chemoradiation. The last course of adjuvant therapy must have been completed > 12
months prior to colorectal cancer recurrence.

- Patients may have received prior standard rectal cancer chemoradiation. Previous
radiation therapy must have been completed >= 4 weeks prior to registration.

- No continuous daily use of vitamin D supplements >= 2,000 IU per day for the 12
months prior to registration. Patients may have had continuous daily use of vitamin
D supplements >= 2,000 IU per day if total duration < 12 months in the 12 months
prior to registration. Patients may have had continuous daily use of vitamin D
supplements < 2,000 IU per day for any duration prior to registration.

- Patients must have completed any major surgery or open biopsy >= 4 weeks prior to
registration and must have completed any minor surgery or core biopsy >= 1 week
prior to registration. (Note: insertion of a vascular access device is not
considered major or minor surgery.) Patients must have recovered from the effects of
any surgery (e.g. wound is healed, no active infection, no drains, etc.) prior to
registration.

- Not pregnant and not nursing. This study involves an agent that has known genotoxic,
mutagenic, and teratogenic effects. Therefore, for women of childbearing potential
only, a negative serum or urine pregnancy test done =< 14 days prior to registration
is required.

- Eastern Cooperative Oncology Group (ECOG) performance status: 0-1.

- Absolute neutrophil count >= 1,500/mm^3.

- Platelet count >= 100,000/mm^3.

- Hemoglobin >= 9 g/dL.

- Creatinine =< 1.5 x upper limit of normal (ULN) OR calculated (Calc.) creatinine
clearance (CrCl) > 30 mL/min.

- Calcium =< 1.0 x ULN.

* Corrected for albumin level if albumin not within institutional limits of normal.

- Total bilirubin =< 1.5 x ULN.

* If Gilbert's disease, use direct bilirubin instead of total bilirubin; direct
bilirubin =< 1.5 x ULN if patient to receive FOLFIRI; direct bilirubin =< 3.0 x ULN
if patient to receive leucovorin, infusional fluorouracil, and oxaliplatin (modified
[m]FOLFOX6).

- Aspartate aminotransferase (AST)/alanine aminotransferase (ALT) =< 2.5 x ULN.

* AST/ALT < 5 x ULN if clearly attributable to liver metastases.

- Urine protein to creatinine (UPC) ratio =< 1 mg/dL OR urine protein =< 1+.

* If urine protein is above 1, then 24-hour urine must be ≤ 1 g/24 hours.

- No resectable metastatic disease for which potentially curative metastasectomy is
planned.

- No "currently active" second malignancy other than non-melanoma skin cancers or
cervical carcinoma in situ. Patients are not considered to have a "currently active"
malignancy if they have completed therapy and have been free of disease for >= 3
years.

- No significant history of bleeding events or bleeding diathesis =< 6 months of
registration unless the source of bleeding has been resected.

- No history of arterial thrombotic events, including, but not limited to, transient
ischemic attack, cerebrovascular accident, unstable angina, angina requiring
surgical or medical intervention, or myocardial infarction =< 6 months of
registration.

- No history of clinically significant peripheral artery disease =< 6 months of
registration.

- No history of uncontrolled congestive heart failure defined as New York Heart
Association (NYHA) class III or greater.

- No history of gastrointestinal (GI) perforation =< 12 months of registration except
for GI perforation related to a primary colorectal tumor that has since been fully
resected.

- No history of malabsorption, uncontrolled vomiting or diarrhea, or any other disease
significantly affecting GI function that could interfere with the absorption of oral
agents.

- No history of allergic reaction attributed to compounds of similar chemical or
biological composition to the study agents.

- No uncontrolled hypertension (defined as blood pressure [BP] > 160/90).

- No serious or non-healing wound, ulcer, or bone fracture.

- No uncontrolled intercurrent illness, including, but not limited to, psychiatric
illness/social situations that, in the opinion of the treating physician, may
increase the risks associated with participation or treatment on the study or may
interfere with the conduct of the study or interpretation of the study results.

- Patients positive for human immunodeficiency virus (HIV) are eligible only if they
meet all of the following:

- On effective anti-retroviral therapy

- Undetectable HIV viral load by standard clinical assay =< 6 months of
registration.

- No known pre-existing hypercalcemia =< 6 months of registration.

- No known active hyperparathyroid disease or other serious disturbance of calcium
metabolism =< 5 years of registration.

- No predisposing colonic or small bowel disorders in which symptoms are uncontrolled
as indicated by > 3 watery or soft stools daily in patients without a colostomy or
ileostomy. Patients with a colostomy or ileostomy are allowed per treating physician
discretion.

- No symptomatic genitourinary stones =< 12 months of registration.

- Patients with treated brain metastases are eligible if follow-up imaging after
central nervous system (CNS)-directed therapy shows no evidence of progression >= 28
days prior to registration.

- Patients with new or progressive brain metastases (active brain metastases) or
leptomeningeal disease are eligible if the treating physician determines that
immediate CNS-specific treatment is not required and is unlikely to be required
during the first cycle of protocol-specified therapy after registration.

- No uncontrolled seizure disorders.

- No grade >=2 peripheral neuropathy, neurosensory toxicity, or neuromotor toxicity
per Common Terminology Criteria for Adverse Events (CTCAE) v5.0 regardless of
causality.

- Patients must be able to swallow oral formulations of the agent.

- Concurrent use of supplemental calcium and/or vitamin D is not permitted. Patients
must discontinue the supplement(s) at least 7 days prior to registration.

- Concurrent use of thiazide diuretics (e.g. hydrochlorothiazide) is not permitted.
Patients must discontinue the drug(s) or switch to an alternative anti-hypertensive
agent at least 7 days prior to registration.

- Chronic concomitant treatment with oral corticosteroids, lithium, phenytoin,
quinidine, isoniazid, and/or rifampin are not permitted. Patients must discontinue
the agent(s) at least 7 days prior to registration. Short-term use of
corticosteroids as antiemetic therapy is acceptable.

- Concurrent use of other anti-cancer therapy including chemotherapy, targeted, and/or
biological agents is not permitted.